About Help FAQ

Symbol
Name
ID

Icos
inducible T cell co-stimulator
MGI:1858745

Phenotype annotations related to hematopoietic system

Darker colors indicate more annotations

Human Phenotypes	Decreased circulating IgA level	Decreased circulating IgG level	Decreased circulating total IgM	Secretory IgA deficiency	Impaired T cell function	Neutropenia in presence of anti-neutropil antibodies	Decreased proportion of class-switched memory B cells	B lymphocytopenia	Abnormal T cell count	Abnormal lymphocyte morphology	Splenomegaly
Disease(s) Associated with ICOS	Decreased circulating IgA level	Decreased circulating IgG level	Decreased circulating total IgM	Secretory IgA deficiency	Impaired T cell function	Neutropenia in presence of anti-neutropil antibodies	Decreased proportion of class-switched memory B cells	B lymphocytopenia	Abnormal T cell count	Abnormal lymphocyte morphology	Splenomegaly
common variable immunodeficiency 1
immunoglobulin alpha deficiency

Mouse Phenotypes

decreased T cell proliferation

abnormal B cell selection

abnormal class switch recombination

abnormal T cell differentiation

abnormal leukocyte cell number

abnormal B cell number

decreased germinal center B cell number

decreased plasma cell number

increased plasma cell number

abnormal memory B cell number

decreased CD4-positive, alpha-beta T cell number

decreased T cell number

abnormal spleen morphology

abnormal spleen germinal center morphology

decreased spleen germinal center number

decreased spleen germinal center size

abnormal B cell physiology

abnormal immunoglobulin level

decreased IgA level

decreased IgE level

decreased IgG1 level

decreased IgG2a level

decreased IgG2b level

decreased IgG2c level

increased IgG3 level

decreased IgG level

abnormal NK cell physiology

abnormal T cell physiology

abnormal CD4-positive, alpha-beta T cell physiology

abnormal T-helper 2 physiology

Availability

Mouse Genotype

Icos^tm1.1Wks/Icos^tm1.1Wks

Icos^tm1Dgry/Icos^tm1Dgry

Icos^tm1Flv/Icos^tm1Flv

Icos^tm1Mak/Icos^tm1Mak

Icos^tm1Shr/Icos^tm1Shr

Icos^tm1Tkan/Icos^tm1Tkan

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23